Colts (2-2) at Texans (1-3), Thursday, 8:25PM

Summary: Andrew Luck is out again and Matt Hasselback isn’t healthy either, but he’ll be the starter for this game. Meanwhile, J.J. Watt and Jadeveon Clowney should be licking their chops at this game with the opportunity to terrorize a backup quarterback. Someone needs to step up for the Colts in this game.

Key Matchup: Texans D-line vs the Colts O-line. No question here. If Watt sets up shop in the backfield, this game could get ugly.

The Pick: Texans. The Colts have struggled even with Andrew Luck and barely got by the Jaguars. Watt and Clowney should have a huge game.

Bills (2-2) at Titans (1-2), Sunday, 1:00PM

Summary: The Bills are, surprisingly, one of the most dangerous teams in the NFL with the combination of a dangerous Rex Ryan defense and Tyrod Taylor and a sparky offense. But with LeSean McCoy and Karlos Williams likely out, they might have trouble getting going. On the other side, this will be the best defense Marcus Mariota will have faced this year. How will he respond?

Key Matchup: Bills D-line vs the Titans O-line. For the Titans to win, they need to give Mariota time to operate. That’s easier said than done against a very, very nasty Bills defensive front.

The Pick: Bills. This might be the best defense in the NFL and they should have a field day with a rookie quarterback.

Browns (1-3) at Ravens (1-3), 1:00PM

Summary: The bottom of the AFC North faces off. The Ravens certainly have the talent to be a better team, but have struggled so far this season. Meanwhile, the Josh McCown-led Browns have been competitive, but you can only go so far with a team led by Josh McCown.

Key Matchup: Steve Smith vs Joe Haden. If Smith is healthy, he’ll be huge for this game. Haden hadn’t had a good year so far, so Joe Flacco might be able to pick on him a bit.

The Pick: Ravens. I don’t trust any team with McCown under center. The Ravens should have a nice bounce back win after their near-miss versus Pittsburgh.

Bears (1-3) at Chiefs (1-3), 1:00PM

Summary: The Bears got their first win on the season with Jay Cutler returning from injury last week. But they have started shopping players around and look to be in rebuilding mode. The Chiefs need to take advantage of this lackluster attitude in this game.

Key Matchup: Bears receivers vs the Chiefs secondary. Rookie cornerback Marcus Peters might be the best rookie defensive back this year, but he’ll have a big test, along with the rest of the secondary, with these Bears receivers, even with Alshon Jeffrey questionable.

The Pick: Chiefs. The Bears are looking ahead to the NFL Draft already and are shopping players. No question here.

Seahawks (2-2) at Bengals (4-0), 1:00PM

Summary: Who would have thought that the Bengals would be 4-0 at this point? Andy Dalton and the Cincinnati offense has been spectacular and the Seahawks defense will have a big test in this game. The Seahawks escaped with a win over the Lions, mainly due to #BatGate, and will face better competition here.

Key Matchup: AJ Green vs Richard Sherman. Just like last week, Sherman will be on Green, the best receiver on the field. If he can lock Green down, it’ll make Dalton’s day that more difficult.

The Pick: Bengals. The Bengals are much more than just AJ Green and Andy Dalton has been very good so far. Meanwhile, the Seahawks have struggled offensively this year.

Rams (2-2) at Packers (4-0), 1:00PM

Summary: Green Bay might have one of the best offenses in the NFL, but they face a Rams defense that has the best front defensive line in the league by far. Rodgers will have to use his arm more in this game, because the running game might not be there.

Key Matchup: Aaron Rodgers vs the Rams D-line. Rodgers is spectacular at moving within the pocket and he’ll have a big test today with Aaron Donald and the rest of the Rams defensive line pressuring him constantly.

The Pick: Packers. They’re just too good, and Rodgers is the best quarterback in the league.

Jaguars (1-3) at Buccaneers (1-3), 1:00PM

Summary: Jameis Winston has struggled, as expected, but faces a much less talented Jags defense in this matchup. Meanwhile, Blake Bortles hasn’t improved all that much either, but faces a Bucs defense that might be able to pressure him more than he’d like.

Key Matchup: Jags receivers vs the Bucs secondary. The Bucs have been torched week in and week out and a Jags receiving core led by Allen Robinson will need to have a huge day to help Blake Bortles.

The Pick: Bucs. Jameis Winston should get back on track and Mike Evans will finally get back to his rookie form. It’s only a matter of time before the two develop a rhythm.

Saints (1-3) at Eagles (1-3), 1:00PM

Summary: The Saints sneaked out a win over the Cowboys in overtime last week and face another NFC East opponent in the Eagles in this matchup. The Eagles are terrible and it’s only a matter of time before Chip Kelly’s experiment comes to an end. Sam Bradford needs to have a huge day, because the Eagles have been terrible running the ball.

Key Matchup: Eagles running game vs the Saints defensive line. The Eagles have been one of the worst running teams in the league. If they can’t run the ball, this one might get ugly.

The Pick: Saints. Drew Brees carved up the Cowboys and there’s no reason to think he won’t have an even better performance against a bad Eagles defense.

Redskins (2-2) at Falcons (4-0), 1:00PM

Summary: Are Matt Ryan, Julio Jones and Devonta Freeman the new Triplets? Seems like it, because those three might be the most explosive players in the NFL so far this season. The Redskins have quietly sneaked out two wins on the season, but they have a tough test against what might be the best offense in the league.

Key Matchup: Julio Jones vs the Redskins secondary. Jones has been lighting up the league so far and the Redskins need to make locking him up a priority. But if they spend too much time on him, it might free up Freeman and the running game.

The Pick: Falcons. No question here. The NFC South was thought to be the weakest division in the NFL, but the Falcons are definitely proving everyone wrong.

Cardinals (3-1) at Lions (0-4), 4:05PM

Summary: The Lions are the lone team in the league without a win, which is surprising considering the individual talent on the team. Meanwhile, the Cardinals have been a major surprise this season with Carson Palmer and Larry Fitzgerald playing like they’re 25 and Patrick Peterson and the secondary locking down receivers.

Key Matchup: Detroit receivers vs the Cardinals secondary. Calvin Johnson hasn’t been a dominant receiver for a while now and faces stiff competition in this Cardinals secondary, who will make life very, very difficult for Matthew Stafford.

The Pick: Cardinals. The Lions might feel like they were robbed of a win over the Seahawks, but this one should be an easy win for the Cards.

Patriots (3-0) at Cowboys (2-2), 4:25PM

Summary: The Cowboys get some reinforcements this week after suffering major injuries in their loss versus the Saints. Greg Hardy and Rolando McClain are back from suspension and it looks like Sean Lee will be healthy as well. Unfortunately, they face Tom Brady, Rob Gronkowski, and one of the best offenses in the league.

Key Matchup: Cowboys D-line vs the Patriots O-line. Greg Hardy and Tyrone Crawford need to get pressure on Brady in this game because if he’s allowed to sit back in the pocket and pick apart this struggling secondary, it could get ugly fast.

The Pick: Patriots. Brandon Weeden almost won the game last week for the Cowboys, but you can never bet against Touchdown Tom.

Broncos (4-0) at Raiders (2-2), 4:25PM

Summary: Derek Carr and Amari Cooper are developing a connection that should scare the rest of the NFL, but they face the best defense in the NFL in this matchup. DeMarcus Ware and Von Miller should have a field day pressuring this young quarterback. Meanwhile, Peyton Manning needs to watch out for Khalil Mack, but should have an easy day in this game.

Key Matchup: Amari Cooper vs the Broncos secondary. Carr will be looking for Cooper early and often, and if he can’t find him, he might be pressured into making mistakes.

The Pick: Broncos. The best defense in the league versus a very young offense. No question here.

49ers (1-3) at Giants (2-2), 8:30PM

Summary: The 49ers have struggled mightily, which was expected of them. The Giants have also struggled, even with all-world Odell Beckham Jr at receiver. This matchup looked a lot more appealing a few year ago, but could become a slop-fest on Sunday night.

Key Matchup: Colin Kaepernick vs the Giants pressure. Kaepernick struggles under pressure and the Giants will bring a ton of it in this game. How he responds will be very key for the 49ers.

The Pick: Giants. Eli Manning and OBJ should have a field day in this one.

Steelers (2-2) at Chargers (2-2), Monday, 8:30PM

Summary: Ben Roethlisberger is still out, which means Michael Vick is still starting for the Steelers. Meanwhile, the Chargers are finally starting to get things going offensively. Le’Veon Bell and Antonio Brown need to have a huge day if Steelers are to have a shot.

Key Matchup: Le’Veon Bell vs the Chargers D-line. Bell will certainly be the bell-cow in this game and how well he plays in this game will definitely be key in this game.

The Pick: Chargers. Not feeling the Steelers in this one, even if Bell and Brown have big days.

BYE: Dolphins, Vikings, Jets, Panthers

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